Overview
- Presents a very up-to date and readable summary of our current understanding of the importance of life before birth, from conception to delivery, and in infancy and childhood, on the subsequent health of the person
- The authors are among the world experts in the areas covered
- Presents critical analysis of experimental paradigms and methodologies and the authors define, for all types of data collection/experimentation, the methods that should be used as ‘world’s best practice’
- Contains chapter summaries and detailed illustrations
- Includes supplementary material: sn.pub/extras
Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 573)
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Table of contents (18 chapters)
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Front Matter
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The Developmental Origins of Health and Disease
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Should we intervene to improve fetal growth?
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Growth and development of human twins
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Practice-induced plasticity in the human motor cortex
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Adaptive Responses of Early Embryos to Their Microenvironment and Consequences for Post-Implantation Development
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Modification of Epigenetic State through Dietary Manipulation in the Developing Mammalian Embryo
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Overview of epigenetic mechanisms
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Nutritional programming and the development of hypertension
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Hypertension in pregnant women
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Developmental Programming of Cardiovascular Dysfunction
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Kidney Development and Fetal Programming
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Programming of Obesity—Experimental Evidence
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Placental delivery of amino acids. Utilization and production vs. transport
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Programming Effects of Excess Glucocorticoid Exposure in Late Gestation
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Back Matter
Keywords
About this book
Early Life Origins of Health and Disease is a new book which presents and discusses the many factors that may have impact on normal development. In a concise and readable manner, the authors consider both the proven and suggestive evidence that the high prevalence of hypertension, diabetes, obesity and, in some populations, kidney disease, may not be all due to genetics or adult environment alone. There is good evidence that stress and more subtle dietary deficiencies, as well as placental malfunction, may increase the risk that the offspring will develop these problems in later life. Finally, new and emerging evidence for other areas of human health and disease such a motor control and mental health is critically reviewed for the first time. The book is a ‘must’ for all scientists interested in researching these areas, as there is a critical evaluation of the methodology used and suggestions for the ‘optimal’ way in which to investigate these phenomena.
Editors and Affiliations
About the editors
Professor Owens is an internationally recognized researcher in developmental physiology and endocrinology and in the early life programming of adult health and disease, diabetes and obesity in particular. She has published over 140 research papers, reviews and book chapters. She has been invited to present numerous plenary lectures or symposia at international or national conferences, and to convene and chair international symposia and plenary sessions at the First, Second and Third World Congresses for the Developmental Origins of Adult Health and Disease (previously Fetal Origins of Adult Disease). She was awarded the McCance Medal for outstanding contributions to perinatal research.
Bibliographic Information
Book Title: Early Life Origins of Health and Disease
Editors: E. Marelyn Wintour, Julie A. Owens
Series Title: Advances in Experimental Medicine and Biology
DOI: https://doi.org/10.1007/0-387-32632-4
Publisher: Springer New York, NY
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 2006
Hardcover ISBN: 978-0-387-28715-7Published: 13 January 2006
Softcover ISBN: 978-1-4419-3950-0Published: 23 November 2010
eBook ISBN: 978-0-387-32632-0Published: 26 February 2007
Series ISSN: 0065-2598
Series E-ISSN: 2214-8019
Edition Number: 1
Number of Pages: XVIII, 228
Topics: Human Physiology, Developmental Biology, Human Genetics, Medicine/Public Health, general, Obstetrics/Perinatology/Midwifery