Skip to main content
SpringerLink
Log in

Rise and Fall of Epithelial Phenotype

Concepts of Epithelial-Mesenchymal Transition

  • Book
  • © 2005

Overview

Authors:
  1. Pierre Savagner

    1. Génotypes et Phénotypes Tumoraux INSERM Bâtiment de Recherche en Cancerologie, CRLC Val d’Aurelle-Paul Lamarque, Montpellier Cedex, France

    View author publications

    You can also search for this author in PubMed   Google Scholar

  • Comprehensive and up-to-date
  • Detailed review of the field
  • Includes supplementary material: sn.pub/extras

Part of the book series: Molecular Biology Intelligence Unit (MBIU)

This is a preview of subscription content, log in via an institution to check access.

Access this book

Log in via an institution
eBook USD 129.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

Licence this eBook for your library

Institutional subscriptions

Table of contents (20 chapters)

  1. Front Matter

    Pages i-xxi
    Download chapter PDF

  2. EMT Concept and Examples from the Vertebrate Embryo

    • Elizabeth D. Hay
    Pages 1-11

  3. Epithelium-Mesenchyme Transitions Are Crucial Morphogenetic Events Occurring during Early Development

    • Olivier G. Morali, Pierre Savagner, Lionel Larue
    Pages 12-28

  4. The Neural Crest

    • Donald F. Newgreen, Sonja J. McKeown
    Pages 29-39

  5. Epithelial-Mesenchymal Transformation in the Embryonic Heart

    • Raymond B. Runyan, Ronald L. Heimark, Todd D. Camenisch, Scott E. Klewer
    Pages 40-55

  6. Epithelial-Extracellular Matrix (Cell-ECM) Interactions in Hydra

    • Michael P. Sarras Jr.
    Pages 56-76

  7. Regulation of the Epithelial-to-Mesenchymal Transition in Sea Urchin Embryos

    • Gary M. Wessel, Hideki Katow
    Pages 77-100

  8. Change of Epithelial Fate

    • Atish Ganguly, Y. Tony Ip
    Pages 101-110

  9. Cutaneous Wound Reepithelialization

    • Valérie Arnoux, Christophe Côme, Donna F. Kusewitt, Laurie G. Hudson, Pierre Savagner
    Pages 111-134

  10. Epithelial-Mesenchymal Transitions in Human Cancer

    • Veerle L. Van Marck, Marc E. Bracke
    Pages 135-159

  11. Structural and Functional Regulation of Desmosomes

    • Spiro Getsios, Lisa M. Godsel, Kathleen J. Green
    Pages 160-177

  12. Epithelial Cell Plasticity by Dynamic Transcriptional Regulation of E-Cadherin

    • Geert Berx, Frans Van Roy
    Pages 178-190

  13. The Regulation of Catenins in Cancer

    • Maralice Conacci-Sorrell, Avri Ben-Ze’ev
    Pages 191-202

  14. Hepatocyte Growth Factor Regulates Transitions between Epithelial and Mesenchymal Cellular Phenotypes during Normal Development and in Disease

    • Regina M. Day, Angelina Felici, Donald P. Bottaro
    Pages 203-214

  15. The Role of Insulin-Like Growth Factors in the Epithelial to Mesenchymal Transition

    • Sylvia Julien-Grille, Robert Moore, Laurence Denat, Olivier G. Morali, Véronique Delmas, Alfonso Bellacosa et al.
    Pages 215-235

  16. TGFβ-Dependent Epithelial-Mesenchymal Transition

    • Marie-Luce Vignais, Patrick Fafet
    Pages 236-244

  17. The Ras and Src Signaling Cascades Involved in Epithelial Cell Scattering

    • Brigitte Boyer
    Pages 245-254

  18. Regulation of E-Cadherin-Mediated Cell-Cell Adhesion by Rho Family GTPases

    • Masato Nakagawa, Nanae Izumi, Kozo Kaibuchi
    Pages 255-266

  19. Wnt Signaling Networks and Embryonic Patterning

    • Michael W. Klymkowsky
    Pages 267-287

  20. Cadherin-Mediated Cell-Cell Adhesion and the Microtubule Network

    • Cécile Gauthier-Rouvière, Marie Causeret, Franck Comunale, Sophie Charrasse
    Pages 288-296
Back to top

Keywords

About this book

Epithelial phenotype is a dynamic stage of differentiation that can be modulated during several physiological or pathological events. The rapid conversion to a mesenchymal-like phenotype is called an epithelial-mesenchymal transition (EMT).

The Rise and Fall of Epithelial Phenotype is the first book to comprehensively introduce the concept of EMT. The first part of this volume describes main examples and models and explains their physiological relevance. These examples include hydra morphogenesis, gastrulation in mouse, drosophila and sea urchin, as well as neural crest cell migration and heart morphogenesis in vertebrates. Part two reviews in detail, specific EMT molecular pathways covering extracellular induction, transduction and transcription response and modulation of cell-cell adhesion structures. It emphasizes new specific pathways with potential medical applications. EMTs can also be linked to pathological events such as wound healing and cancer progression, as detailed in this section of the book.

Authors and Affiliations

  • Génotypes et Phénotypes Tumoraux INSERM Bâtiment de Recherche en Cancerologie, CRLC Val d’Aurelle-Paul Lamarque, Montpellier Cedex, France

    Pierre Savagner

Bibliographic Information

  • Book Title: Rise and Fall of Epithelial Phenotype

  • Book Subtitle: Concepts of Epithelial-Mesenchymal Transition

  • Authors: Pierre Savagner

  • Series Title: Molecular Biology Intelligence Unit

  • DOI: https://doi.org/10.1007/0-387-28671-3

  • Publisher: Springer New York, NY

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer-Verlag US 2005

  • Hardcover ISBN: 978-0-306-48239-7Published: 13 July 2005

  • Softcover ISBN: 978-1-4419-3439-0Published: 01 December 2010

  • eBook ISBN: 978-0-387-28671-6Published: 05 July 2007

  • Series ISSN: 1431-0414

  • Edition Number: 1

  • Number of Pages: 248

  • Number of Illustrations: 99 b/w illustrations, 2 illustrations in colour

  • Topics: Cell Biology, Developmental Biology, Cancer Research

Publish with us

Policies and ethics

Back to top

Search

Navigation