Myocardial Ischemia

1. Front Matter

   Pages i-ix

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2. From Fetal to Fatal

   • Heinrich Taegtmeyer

   Pages 1-9

3. Myocardial Ischemia

   • Constantinos Pantos, Iordanis Mourouzis, Dennis V. Cokkinos

   Pages 11-76

4. Hormones Signaling and Myocardial Ischemia

   • Constantinos Pantos, Dennis V. Cokkinos

   Pages 77-98

5. Ischemic Preconditioning

   • James M. Downey, Michael V. Cohen

   Pages 99-112

6. Connexin 43 and Ischemic Preconditioning

   • Rainer Schulz, Gerd Heusch

   Pages 113-125

7. Coronary Microembolization

   • Andreas Skyschally, Rainer Schulz, Michael Haude, Raimund Erbel, Gerd Heusch

   Pages 127-144

8. Fibroblast Growth Factor-2

   • Elissavet Kardami, Karen A. Detillieux, Sarah K. Jimenez, Peter A. Cattini

   Pages 145-166

9. Myocardial Protection — From Concepts to Clinical Practice

   • Dennis V. Cokkinos

   Pages 167-198

10. A Synopsis

    • Dennis V. Cokkinos

    Pages 199-200

11. Back Matter

    Pages 201-204

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Effective new treatments of heart disease are based on a refined understanding of cellular function and the heart's response to environmental stresses. Not surprisingly therefore, the field of experimental cardiology has experienced a phase of rapid expo­ nential growth during the last decade. The acquisition of new knowledge has been so fast that textbooks of cardiology or textbooks of cardiovascular physiology are often hard-pressed to keep up with the most important conceptual advances. Witness the explosive increase in knowledge about signaling pathways of cardiac growth, transcrip­ tional regulation of cardiac metabolism, hormonal signaling, and the complex responses of the heart to ischemia, reperfusion, or ischemic preconditioning. This book is meant to bridge the gap between original literature and textbook reviews. It brings together inves­ tigators of various backgrounds who share their expertise in the biology of myocardial ischemia. Each chapter is a self-contained mini-review, but it will soon become apparent to the reader that there is also a common thread: Molecular and cellular cardiology has never been more exciting than now, but ever more exciting times are yet to come. The Editors ACKNOWLEDGEMENTS - Publication of this book was generously supported by Sanofi-Aventis Hellas. - Eikon creative team provided the technical assistance in preparing the manuscripts. - We thank Dr. Bernard Swynghedauw for all his scientific support.

• adaptation
• development
• growth
• growth factor
• heart
• heart disease
• hormone
• hormones
• pathophysiology
• physiology
• stress

• Cardiology Dept., Onassis Cardiac Surgery Center, University of Athens, Athens, Greece

  Dennis V. Cokkinos

• Depart. Of Pharmacology, Medical School, University of Athens, Athens, Greece

  Constantinos Pantos

• Institute of Pathophysiology, Department of Internal Medicine, University of Essen, Essen, Germany

  Gerd Heusch

• Division of Cardiology, The University of Texas Houston Medical School, Houston, USA

  Heinrich Taegtmeyer

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