Overview
- Editors:
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Jonathan J. Li
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Division of Etiology and Prevention of Hormonal Cancers, The University of Kansas Medical Center, Kansas City
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Sara A. Li
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Division of Etiology and Prevention of Hormonal Cancers, The University of Kansas Medical Center, Kansas City
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Antonio Llombart-Bosch
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Departmento de Patologia, Facultad de Medicina y Odontologia, Valencia, Spain
- Covers a group of hormonally-associated cancers that present interesting challenges to clinicians and biomedical researchers
- Addresses vital questions that impact our understanding of the causation, dependency, progression, resistance, and prevention of these types of cancers
- Includes supplementary material: sn.pub/extras
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Table of contents (58 chapters)
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Front Matter
Pages i-xxvi
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Symposium Address
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- William R. Brinkley, David L. Stenoien, Thea Goepfert
Pages 1-16
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State of the Art Lectures
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- Jonathan J. Li, Jeffrey Salisbury, Sara Antonia Li
Pages 19-33
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- William G. Nelson, Angelo M. DeMarzo, Theodore L. DeWeese, William B. Isaacs
Pages 34-44
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Breast Cancer I: Progesterone Action
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- Henri Rochefort, Majida Esslimani-Sahla, Dany Chalbos
Pages 65-76
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Breast Cancer II: Mechanisms of Genomic Instability
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- Sabine Mai, Amanda Guffei, Thierry Fest, J. Frederic Mushinski
Pages 87-97
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- Charles H. Spruck, Adrian P. L. Smith, Susanna Ekholm Reed, Olle Sangfelt, Jaimie Keck, Heimo Strohmaier et al.
Pages 98-105
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Breast and Prostate: Early In-Situ Lesions
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Front Matter
Pages 119-119
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- Rajeshwar Rao Tekmal, Nameer Kirma, Usha Mandava, Roopa Luthra
Pages 130-140
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- Cristina Magi-Galluzzi, Angelo M. De Marzo
Pages 141-150
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Promotion/Prevention of Hormone Cancers
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Front Matter
Pages 151-151
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- Satyabrata Nandi, Raphael C. Guzman, Gudmundur Thordarson, Lakshmanaswamy Rajkumar
Pages 153-165
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About this book
It has been over a decade since the First International Symposium on Hormonal Carcinogenesis convened in 199 1. Since then, the field has rapidly expanded with considerable progress in both breast and prostate cancers; while ovarian and endometrial cancer have been hampered, in part, due to the absence of suitable hormone-mediated animal models. While knock-out, transgenic, and cell-culture systems have been extremely useful in identifying specific genelprotein alterations and the ensuing pathways affected, the precise molecular mechanisms whereby sex hormones elicit their oncogenic effects still remain elusive. Moreover, despite the considerable progress made in breast cancer research, the exact role of progestins in the presence or absence of estrogen in breast growth, differentiation, and malignant transformation is lacking. Elucidating the incipient molecular alterations in earlylpre-invasive lesions elicited by these hormones is a growing important focus of this field. The main purpose of these Symposia has been to address vital questions that impact our understanding of the causation, dependency, progression, resistance, and prevention of hormonally-associated cancers. We are indebted to the Scientific Advisory Board members who worked with us reviewing and offering suggestions to finalize the scientific program. We offer special thanks for the guidance and support of Dr. Gerald Mueller. His wisdom played an indispensable role in maintaining the excellence of these Symposia. We also acknowledge the numerous external reviewers that worked diligently to revise and improve the quality of the manuscripts. We are very grateful to Ms. Tandria Price.
