Hormonal Carcinogenesis IV

1. Front Matter

   Pages i-xxvi

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2. Symposium Address

   1. Symposium Address

      • William R. Brinkley, David L. Stenoien, Thea Goepfert

      Pages 1-16

3. State of the Art Lectures

   1. Front Matter

      Pages 17-17

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   2. Chromosomal Instability: A New Paradigm for Estrogen-induced Oncogenesis

      • Jonathan J. Li, Jeffrey Salisbury, Sara Antonia Li

      Pages 19-33

   3. The Molecular Pathogenesis of Human Prostate Cancer

      • William G. Nelson, Angelo M. DeMarzo, Theodore L. DeWeese, William B. Isaacs

      Pages 34-44

4. Breast Cancer I: Progesterone Action

   1. Front Matter

      Pages 45-45

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   2. Pathologic, Clinical, and Epidemiologic Characteristics of Invasive Lobular Breast Carcinoma and a Review of Studies Evaluating its Association with Hormone Replacement Therapy

      • Christopher I. Li

      Pages 47-64

   3. Progestin-Regulated Genes and Breast Cancer Risk: Good or Bad?

      • Henri Rochefort, Majida Esslimani-Sahla, Dany Chalbos

      Pages 65-76

   4. Role of Progesterone Receptors in Mammary Development and Carcinogenesis

      • Gopalan Shyamala

      Pages 77-84

5. Breast Cancer II: Mechanisms of Genomic Instability

   1. Front Matter

      Pages 85-85

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   2. c-Myc Deregulation Promotes a Complex Network of Genomic Instability

      • Sabine Mai, Amanda Guffei, Thierry Fest, J. Frederic Mushinski

      Pages 87-97

   3. Deregulation of Cyclin E and Genomic Instability

      • Charles H. Spruck, Adrian P. L. Smith, Susanna Ekholm Reed, Olle Sangfelt, Jaimie Keck, Heimo Strohmaier et al.

      Pages 98-105

   4. Centrosome Amplification and the Origin of Chromosomal Instability in Breast Cancer

      • Jeffrey L. Salisbury

      Pages 106-118

6. Breast and Prostate: Early In-Situ Lesions

   1. Front Matter

      Pages 119-119

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   2. Premalignant Breast Disease: Anatomic Lesions and Hormonal Associations

      • David L. Page

      Pages 121-129

   3. Aromatase Overexpression: Effect of Tissue Estrogen on Phenotypic and Biochemical Changes in Aromatase Transgenic Mice

      • Rajeshwar Rao Tekmal, Nameer Kirma, Usha Mandava, Roopa Luthra

      Pages 130-140

   4. Prostate Epithelial Carcinogenesis: Putative and Controversial Precursor Lesions

      • Cristina Magi-Galluzzi, Angelo M. De Marzo

      Pages 141-150

7. Promotion/Prevention of Hormone Cancers

   1. Front Matter

      Pages 151-151

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   2. Estrogen Can Prevent Breast Cancer by Mimicking the Protective Effect of Pregnancy

      • Satyabrata Nandi, Raphael C. Guzman, Gudmundur Thordarson, Lakshmanaswamy Rajkumar

      Pages 153-165

   3. Aromatase Inhibition and Breast Cancer

      • William R. Miller

      Pages 166-180

It has been over a decade since the First International Symposium on Hormonal Carcinogenesis convened in 199 1. Since then, the field has rapidly expanded with considerable progress in both breast and prostate cancers; while ovarian and endometrial cancer have been hampered, in part, due to the absence of suitable hormone-mediated animal models. While knock-out, transgenic, and cell-culture systems have been extremely useful in identifying specific genelprotein alterations and the ensuing pathways affected, the precise molecular mechanisms whereby sex hormones elicit their oncogenic effects still remain elusive. Moreover, despite the considerable progress made in breast cancer research, the exact role of progestins in the presence or absence of estrogen in breast growth, differentiation, and malignant transformation is lacking. Elucidating the incipient molecular alterations in earlylpre-invasive lesions elicited by these hormones is a growing important focus of this field. The main purpose of these Symposia has been to address vital questions that impact our understanding of the causation, dependency, progression, resistance, and prevention of hormonally-associated cancers. We are indebted to the Scientific Advisory Board members who worked with us reviewing and offering suggestions to finalize the scientific program. We offer special thanks for the guidance and support of Dr. Gerald Mueller. His wisdom played an indispensable role in maintaining the excellence of these Symposia. We also acknowledge the numerous external reviewers that worked diligently to revise and improve the quality of the manuscripts. We are very grateful to Ms. Tandria Price.

• biology
• cancer
• carcinogenesis
• cell
• endometrium
• hormones
• liver
• metabolism
• molecular biology
• ovarian cancer
• prevention
• prostate cancer
• resistance

• Division of Etiology and Prevention of Hormonal Cancers, The University of Kansas Medical Center, Kansas City

  Jonathan J. Li, Sara A. Li

• Departmento de Patologia, Facultad de Medicina y Odontologia, Valencia, Spain

  Antonio Llombart-Bosch

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