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Functional Tissue Engineering

  • Book
  • © 2003

Overview

Editors:
  1. Farshid Guilak

    1. Orthopaedic Research Laboratories Department of Surgery 375 MSRB, Duke University Medical Center, Durham, USA

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  2. David L. Butler

    1. Department of Biomedical Engineering, University of Cincinnati, Cincinnati, USA

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  3. Steven A. Goldstein

    1. Orthopaedic Research Laboratories, University of Michigan, Ann Arbor, USA

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  4. David J. Mooney

    1. Department of Biologic and Materials Sciences, University of Michigan, Ann Arbor, USA

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  • Chapters written by well-known researchers discuss these matters and provide guidelines and a summary of the current state of technology in functional tissue engineering

  • Will serve as a reference and teaching text for the rapidly increasing population of students and investigators in the field of tissue engineering

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Table of contents (30 chapters)

  1. Front Matter

    Pages i-xvi
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  2. The Functional Properties of Native Tissues

    1. Front Matter

      Pages 1-1
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    2. How Does Nature Build a Tissue?

      • Stephen C. Cowin
      Pages 3-16

    3. Ligament Healing: Present Status and the Future of Functional Tissue Engineering

      • Savio L-Y. Woo, Steven D. Abramowitch, John C. Loh, Volker Musahl, James H-C. Wang
      Pages 17-34

    4. Native Properties of Cardiovascular Tissues: Guidelines for Functional Tissue Engineering

      • Jay D. Humphrey
      Pages 35-45

    5. Functional Properties of Native Articular Cartilage

      • Gerard A. Ateshian, Clark T. Hung
      Pages 46-68

    6. Excitability and Contractility of Skeletal Muscle: Measurements and Interpretations

      • John A. Faulkner, Robert G. Dennis
      Pages 69-83

  3. Functional Requirements of Engineered Tissues

    1. Front Matter

      Pages 85-85
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    2. Functional Requirements for the Engineering of a Blood Vessel Substitute

      • Robert M. Nerem, Jan P. Stegemann
      Pages 87-95

    3. In Vivo Force and Strain of Tendon, Ligament, and Capsule

      • Kai-Nan An
      Pages 96-105

    4. Requirements for Biological Replacement of the Articular Cartilage at the Knee Joint

      • Thomas Andriacchi
      Pages 106-116

    5. Functional Requirements: Cartilage

      • Jack L. Lewis
      Pages 117-126

  4. Design Parameters for Tissue Engineering

    1. Front Matter

      Pages 127-127
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    2. Design Parameters For Functional Tissue Engineering

      • Arnold I. Caplan
      Pages 129-138

    3. Tissue Engineering a Heart: Critical Issues

      • Michael V. Sefton, Robert Akins
      Pages 139-145

    4. Design Parameters for Engineering Bone Regeneration

      • Robert E. Guldberg, Angel O. Duty
      Pages 146-161

    5. Tissue Engineering of Bone: The Potential Use of Gene Therapy for Difficult Bone Loss Problems

      • Brett Peterson, Jay R. Lieberman
      Pages 162-177

    6. Engineered Skeletal Muscle: Functional Tissues, Organs, and Interfaces

      • Robert G. Dennis
      Pages 178-193

    7. Bioengineering the Growth of Articular Cartilage

      • Stephen M. Klisch, Michael A. DiMicco, Anne Hoger, Robert L. Sah
      Pages 194-210

  5. Assessment of Junction in Engineered Tissues

    1. Front Matter

      Pages 211-211
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Keywords

About this book

Tissue engineering is an exciting new field at the interface of engineering and - ology that uses implanted cells, scaffolds, DNA, proteins, protein fragments, and inductive molecules to repair or replace injured or diseased tissues and organs. Tremendous progress in biological and biomaterial aspects of this field have been accomplished to date, and several engineered tissues are now being used clinically. However, tissue engineers face major challenges in repairing or repl- ing tissues that serve a predominantly biomechanical function. To meet this challenge, the United States National Committee on Biomech- ics in 1998 adopted a new paradigm termed functional tissue engineering (FTE) to emphasize the importance of biomechanical considerations in the design and - velopment of cell and matrix-based implants for soft and hard tissue repair. Functional tissue engineering represents a relevant and exciting new discipline in the field of tissue engineering. Since many tissues, such as those of the muscu- skeletal, cardiovascular, and dental systems, are accustomed to being mecha- cally challenged, tissue-engineered constructs used to replace these tissues after injury or disease must certainly do the same. Of course, tissue engineers must also attempt to return normal biological activity in order for the construct to truly - tegrate with the surrounding tissues. Thus, the term functional can have many meanings, such as restoration of metabolic function. The primary focus of this text is on the role of biomechanical function in tissue engineering.

Reviews

From the reviews:

"Functional Tissue Engineering is a useful compilation of research by contributors involved in developing tissues … . It is not easy to extract a decent book from a conference, but the editors have done a very good job … . it will be an invaluable source for those starting a PhD … . I recommend it to those embarking on or already involved in engineering structural tissues. … The chapters are well written … . The book is clearly focused to encompass practical issues, such as the need to create appropriate biomechanical environments … ." (Sheila MacNeil, Materials Today, July/August, 2005)

Editors and Affiliations

  • Orthopaedic Research Laboratories Department of Surgery 375 MSRB, Duke University Medical Center, Durham, USA

    Farshid Guilak

  • Department of Biomedical Engineering, University of Cincinnati, Cincinnati, USA

    David L. Butler

  • Orthopaedic Research Laboratories, University of Michigan, Ann Arbor, USA

    Steven A. Goldstein

  • Department of Biologic and Materials Sciences, University of Michigan, Ann Arbor, USA

    David J. Mooney

Bibliographic Information

  • Book Title: Functional Tissue Engineering

  • Editors: Farshid Guilak, David L. Butler, Steven A. Goldstein, David J. Mooney

  • DOI: https://doi.org/10.1007/b97260

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag New York 2003

  • Hardcover ISBN: 978-0-387-95553-7Published: 09 July 2003

  • Softcover ISBN: 978-0-387-22013-0Published: 25 August 2004

  • eBook ISBN: 978-0-387-21547-1Published: 20 April 2006

  • Edition Number: 1

  • Number of Pages: XVI, 426

  • Topics: Cell Biology, Orthopedics, Biomedical Engineering and Bioengineering

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