Infectious Diseases and Substance Abuse

1. Front Matter

   Pages i-xx

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2. Effects of Cocaine and Morphine Withdrawal on the Immune Response

   • Albert H. Avila, Norma C. Alonzo, Barbara M. Bayer

   Pages 1-11

3. Biological Links between Cannabinoids and HIV Infection

   • Gayle C. Baldwin, Michael D. Roth

   Pages 13-32

4. Cannabinoids and Herpesviruses

   • Jerry L. Bulen, Peter G. Medveczky

   Pages 33-49

5. Cannabinoids and Susceptibility to Neurological Infection by Free-Living Amebae

   • Guy A. Cabral, Francine Marciano-Cabral

   Pages 51-65

6. Legionella Infection and Cannabinoids

   • Herman Friedman, Catherine Newton, Thomas W. Klein

   Pages 67-75

7. Nicotine and Immunity

   • Susan Pross, Herman Friedman

   Pages 77-92

8. Nicotine Receptors and Infections

   • Yoshimasa Yamamoto

   Pages 93-102

9. Immunomodulatory Effects of Cigarette Smoke/Nicotine

   • Mohan L. Sopori, Seddigheh Razani-Boroujerdi, Shashi P. Singh

   Pages 103-109

10. Regulation of Chemokine and Chemokine Receptor Expression and Function by Opioids

    • Filip Bednar, Amber D. Steele, David E. Kaminsky, Penelope C. Davey, Thomas J. Rogers

    Pages 111-123

11. Morphine, Th1/Th2 Differentiation, and Susceptibility to Infection

    • Sabita Roy, Jing-Hua Wang, Roderick A. Barke

    Pages 125-140

12. Immunofluorescence Detection of Anti-CD3-ε-Induced Delta Opioid Receptors by Murine Splenic T Cells

    • Burt M. Sharp, Kathy McAllen, Nahid A. Shahabi

    Pages 141-147

13. Modulation of Immune Function by Novel Opioid Receptor Ligands

    • Richard Weber, Ricardo Gomez

    Pages 149-158

14. Effect of Alcohol on Microbial Infection

    • Yoshimasa Yamamoto, Herman Friedman

    Pages 159-169

15. Brucella Infection and Ethanol

    • Zeki Yumuk

    Pages 171-177

16. Alcohol, Infection, and the Lung

    • Ping Zhang, Gregory J. Bagby, Jay K. Kolls, Lee J. Quinton, Steve Nelson

    Pages 179-195

17. Back Matter

    Pages 197-211

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The use of recreational drugs of abuse by large numbers of individuals in this country and abroad has aroused serious concerns about the consequences of this activity. For example, it is recognized that marijuana is currently widely used as a recreational drug in the United States as well as other countries. Similarly, abuse of cocaine, especially crack cocaine, is considered to be an epidemic. “The war on drugs” by the US Government was directly aimed at the illicit use of cocaine, marijuana, and opiates as well as other drugs of abuse. Furthermore, alcohol is also considered a major problem of abuse in this country as well as in many other countries. It is estimated there are at least 10 million alcoholics in the United States alone. A signi?cant portion of those hospitalized with infectious diseases are alcoholics. Similarly, there have been many reports of association between marijuana use and increased susceptibility to infection as well as a re- tion between use of opiates and infections. The relationship between drug abuse and increased incidence of various infections has stimulated increased investi- tion of whether and how such drugs affect immune function, especially imp- tant for resistance against infectious agents. During the last decades, a wide variety of studies have shown that drugs of abuse, including marijuana, cocaine, or opiates, as well as alcohol, alter both neurophysiological as well as pathological responses of individuals.

• Chemokine
• HIV
• HIV infection
• bacteria
• infection
• infections
• infectious
• infectious disease
• infectious diseases
• interferon
• virus

• Department of Medical Microbiology and Immunology, University of South Florida College of Medicine, Tampa

  Herman Friedman, Thomas W. Klein

• Department of Experimental Pathology, University of Pisa, Pisa, Italy

  Mauro Bendinelli

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