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Viral Membrane Proteins: Structure, Function, and Drug Design

  • Book
  • © 2005

Overview

Editors:
  1. Wolfgang B. Fischer

    1. Department of Biochemistry, University of Oxford, UK

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  • First book in the new series Protein Reviews
  • Written by renowned leaders in the field, this volume summarizes the current structural and functional knowledge of membrane proteins encoded by viruses while at the same time addressing questions about the proteins as potential drug targets, thus providing the most comprehensive volume in this field of research

Part of the book series: Protein Reviews (PRON, volume 1)

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Table of contents (18 chapters)

  1. Front Matter

    Pages i-xviii
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  2. Membrane Proteins from Plant Viruses

    1. Front Matter

      Pages 1-1
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    2. Membrane Proteins in Plant Viruses

      • Michael J. Adams, John F. Antoniw
      Pages 3-19

    3. Structure and Function of a Viral Encoded K+ Channel

      • Anna Moroni, James Van Etten, Gerhard Thiel
      Pages 21-32

  3. Fusion Proteins

    1. Front Matter

      Pages 33-33
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    2. HIV gp41: A Viral Membrane Fusion Machine

      • Sergio G. Peisajovich, Yechiel Shai
      Pages 35-47

    3. Diversity of Coronavirus Spikes: Relationship to Pathogen Entry and Dissemination

      • Edward B. Thorp, Thomas M. Gallagher
      Pages 49-63

    4. Aspects of the Fusogenic Activity of Influenza Hemagglutinin Peptides by Molecular Dynamics Simulations

      • L. Vaccaro, K. J. Cross, S. A. Wharton, J. J. Skehel, F. Fraternali
      Pages 65-75

  4. Viral Ion Channels/viroporins

    1. Front Matter

      Pages 77-77
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    2. Viral Proteins that Enhance Membrane Permeability

      • María Eugenia González, Luis Carrasco
      Pages 79-90

    3. FTIR Studies of Viral Ion Channels

      • Itamar Kass, Isaiah T. Arkin
      Pages 91-100

    4. The M2 Proteins of Influenza A and B Viruses are Single-Pass Proton Channels

      • Yajun Tang, Padmavati Venkataraman, Jared Knopman, Robert A. Lamb, Lawrence H. Pinto
      Pages 101-111

    5. Influenza A Virus M2 Protein: Proton Selectivity of the Ion Channel, Cytotoxicity, and a Hypothesis on Peripheral Raft Association and Virus Budding

      • Cornelia Schroeder, Tse-I Lin
      Pages 113-130

    6. Computer Simulations of Proton Transport Through the M2 Channel of the Influenza A Virus

      • Yujie Wu, Gregory A. Voth
      Pages 131-145

    7. Structure and Function of Vpu from HIV-1

      • S. J. Opella, S. H. Park, S. Lee, D. Jones, A. Nevzorov, M. Mesleh et al.
      Pages 147-163

    8. Structure, Phosphorylation, and Biological Function of the HIV-1 Specific Virus Protein U (Vpu)

      • Victor Wray, Ulrich Schubert
      Pages 165-175

    9. Solid-State NMR Investigations of Vpu Structural Domains in Oriented Phospholipid Bilayers: Interactions and Alignment

      • Burkhard Bechinger, Peter Henklein
      Pages 177-186

    10. Defining Drug Interactions with the Viral Membrane Protein Vpu from HIV-1

      • V. Lemaitre, C. G. Kim, D. Fischer, Y. H. Lam, A. Watts, W. B. Fischer
      Pages 187-205

    11. Virus Ion Channels Formed by Vpu of HIV-1, the 6K Protein of Alphaviruses and NB of Influenza B Virus

      • Peter W. Gage, Gary Ewart, Julian Melton, Anita Premkumar
      Pages 207-231

    12. The Alphavirus 6K Protein

      • M. A. Sanz, V. Madan, J. L. Nieva, Luis Carrasco
      Pages 233-244
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Keywords

About this book

In Viral Membrane Proteins: Structure, Function, and Drug Design, Wolfgang Fischer summarizes the current structural and functional knowledge of membrane proteins encoded by viruses. In addition, contributors to the book address questions about proteins as potential drug targets. The range of information covered includes signal proteins, ion channels, and fusion proteins.

This book has a place in the libraries of researchers and scientists in a wide array of fields, including protein chemistry, molecular biophysics, pharmaceutical science and research, bioanotechnology, molecular biology, and biochemistry.

Editors and Affiliations

  • Department of Biochemistry, University of Oxford, UK

    Wolfgang B. Fischer

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