Free Radicals, Oxidative Stress, and Antioxidants

1. Front Matter

   Pages i-ix

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2. Mechanisms Involved in Free Radical Reactions

   1. Iron in Free Radical Reactions and Antioxidant Protection

      • John M. C. Gutteridge

      Pages 1-14

   2. Non-Chelation Dependent Redox Actions of Desferrioxamine

      • Ben-Zhan Zhu, Ronit Har-El, Nahum Kitrossky, Mordechai Chevion

      Pages 15-24

   3. The Effects of Oxidative Stress on the Redox System of the Human Erythrocyte

      • İ. Hamdi Öğüş, Mevhibe Balk, Yasemin Aksoy, Meltem Müftüoğlu, Nazmi Özer

      Pages 25-37

   4. Free Radicals as Reagents for Electron Transfer Processes in Proteins

      • I. Pecht, O. Farver

      Pages 39-49

   5. Free Radical Mediated Oxidation of Proteins

      • Earl R. Stadtman

      Pages 51-64

   6. Nitric Oxide Regulation of Membrane and Lipoprotein Oxidation in the Vasculature

      • Bruce A. Freeman, Jason Eiserich, Valerie O’Donnell

      Pages 65-78

   7. Apolipoprotein E Oxidation Through Enzymes Localized into the Brain

      • B. Leininger-Muller, C. Jolivalt, R. Herber, P. Bertrand, G. Siest

      Pages 79-84

   8. Flavonoid Radicals

      • Wolf Bors, Christa Michel, Werner Heller, Heinrich Sandermann Jr.

      Pages 85-92

   9. The Molecular Mechanism of Interaction of H2O2 with Metmyoglobin

      • Dimitrios Galaris, Stelianos Kokkoris, Ioannis Toumpoulis, Panagiotis Korantzopoulos

      Pages 93-101

   10. Are Free Radicals Involved in the Expression of Adhesion Molecules?

       • W. Sluiter, A. Pietersma, J. F. Koster

       Pages 103-108

3. Free Radicals in Health and Disease

   1. Reactive Oxygen Species (ROS) and Alteration of F0F1-ATP Synthase in Aging and Liver Regeneration

      • Ferruccio Guerrieri, Giovanna Pellecchia, Sergio Papa

      Pages 109-119

   2. Free Radicals and Antioxidants in Physical Exercise

      • José Viña, Miguel Asensi, Juan Sastre, José A. Ferrero, Emilio Servera, Amparo Gimeno et al.

      Pages 121-129

   3. The Role of Free Radical Mediation of Protein Oxidation in Aging and Disease

      • Earl R. Stadtman

      Pages 131-143

   4. Oxidative Damage and Fibrosclerosis in Various Tissues

      • Antonella Scavazza, Gabriella Leonarduzzi, Simonetta Camandola, Maurizio Parola, Giuseppe Poli

      Pages 145-149

   5. The Role of Free Radicals in Ischemic Injury and the Precondition Status

      • J. F. Koster, W. Sluiter

      Pages 151-155

   6. Oxidative Damage and Reperfusion Syndrome in Human Liver Transplantation

      • Fiorella Biasi, Juan Cutrin, Elena Chiarpotto, Mauro Salizzoni, Alessandro Franchello, Fausto Zamboni et al.

      Pages 157-162

   7. Pathophysiology of Cerebral Ischemia

      • Tomris Özben

      Pages 163-187

   8. The Role of Free Radicals in NMDA and Glutamate Excitotoxicity

      • A. S. Yalçın, Goncagül Haklar, Belgin Küçükkaya, Meral Yüksel, Hale Saybaşılı

      Pages 189-193

   9. The Role of Oxidative Stress in the Pathological Sequelae of Alzheimer Disease

      • Mark A. Smith, George Perry

      Pages 195-204

There has been an explosion of research related to free radicals and antioxidants in recent years, and hundreds of laboratories worldwide are actively involved in many as­ pects of free radicals, oxidative stress, and antioxidants. The literature on these topics in­ creases exponentially every year. Over the last few years, we have been fortunate to witness a widespread recognition of the important role of free radicals in a wide variety of pathological conditions including diseases such as atherosclerosis, cardiovascular and neurological diseases, ischemia, emphysema, diabetes, radiation injury, cancer, etc. In ad­ dition, many laboratories are studying the role of free radicals in the inexorable process of aging. Increased evidence involves free radicals with the etiology of various diseases, thereby suggesting the use of antioxidants as a viable therapeutic approach for the treat­ ment of free radical mediated pathologies. Despite these impressive developments, many important aspects of free radical and antioxidant research are open for investigation. It is important to understand the overall mechanisms involved in free radical mediated physiological and pathological conditions. This knowledge will undoubtedly lead to the development of new therapeutic approaches to prevent or control free radical related diseases. This book contains the proceedings of the NATO Advanced Study Institute (ASI) on "Free Radicals, Oxidative Stress, and Antioxidants: Pathological and Physiological Sig­ nificance," which was held in Antalya, Turkey from May 24-June 4, 1997.

• ATP
• Oxidation
• aging
• antioxidant
• cancer
• oxidative stress
• protein
• regeneration
• spectroscopy

• Akdeniz University, Antalya, Turkey

  Tomris Özben

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