Reactive Oxygen Species in Biological Systems: An Interdisciplinary Approach

1. Front Matter

   Pages i-xxv

   PDF

2. Introduction

   1. Front Matter

      Pages 1-1

      PDF

   2. From the Breath of Life to Reactive Oxygen Species

      • Daniel L. Gilbert

      Pages 3-31

   3. Chemistry of Reactive Oxygen Species

      • Robert E. Huie, P. Neta

      Pages 33-73

3. General Biochemistry and Molecular Biology

   1. Front Matter

      Pages 75-75

      PDF

   2. The Steady-State Concentrations of Oxygen Radicals in Mitochondria

      • Cecilia Giulivi, Alberto Boveris, Enrique Cadenas

      Pages 77-102

   3. The Role of Transition Metal Ions in Free Radical-Mediated Damage

      • Mordechai Chevion, Eduard Berenshtein, Ben-Zhan Zhu

      Pages 103-131

   4. Biochemistry of Redox Signaling in the Activation of Oxidative Stress Genes

      • Beatriz González-Flecha, Bruce Demple

      Pages 133-153

   5. Regulation of Mammalian Gene Expression by Reactive Oxygen Species

      • Dana R. Crawford

      Pages 155-171

   6. Inflammatory Regulation of Manganese Superoxide Dismutase

      • John F. Valentine, Harry S. Nick

      Pages 173-187

   7. Antioxidant Protection and Ixygen Radical Signaling

      • John M. C. Gutteridge, Barry Halliwell

      Pages 189-218

4. Nitrogen Reactive Species

   1. Front Matter

      Pages 219-219

      PDF

   2. Nitric Oxide Synthase

      • Nicolas J. Guzman, Bismark Amoah-Apraku

      Pages 221-243

   3. The Chemical Biology of Nitric Oxide

      • David A. Wink, Martin Feelisch, Yoram Vodovotz, Jon Fukuto, Matthew B. Grisham

      Pages 245-291

   4. Nitroxides as Protectors Against Oxidative Stress

      • James B. Mitchell, Murali C. Krishna, Amram Samuni, Angelo Russo, Stephen M. Hahn

      Pages 293-313

5. Environmental Pro- and Antioxidants

   1. Front Matter

      Pages 315-315

      PDF

   2. Stratospheric Ozone and Its Effects on the Biosphere

      • Sasha Madronich

      Pages 317-334

   3. Ozone and Nitrogen Dioxide

      • Daniel B. Menzel, Dianne M. Meacher

      Pages 335-366

   4. Dietary Antioxidants and Nutrition

      • Catherine Rice-Evans, Saimar Arif

      Pages 367-393

6. Internal Pro- and Antioxidants

   1. Front Matter

      Pages 395-395

      PDF

Reactive oxygen species (ROS) which include free radicals, peroxides, singlet oxygen, ozone, and nitrogen monoxide and dioxide free radicals, is an area of intense research. This volume covers (1) the destruction of cellular function by ROS resulting in pathological states; (2) the protection by ROS of an organism against invading organisms that cause infections; and (3) the role of ROS in normal physiological processes. Designed for beginning graduate students, this book gives a concise overview of the field.

• Alzheimer
• Oxidation
• Parkinson
• biochemistry
• gene expression
• inflammation

• National Institutes of Health, Bethesda

  Daniel L. Gilbert

• Georgetown University Medical School, Washington, D.C.

  Carol A. Colton

Policies and ethics