Aspergillus and Aspergillosis

1. Front Matter

   Pages i-x

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2. Keynote Lecture

   1. Keynote Lecture

      • Donald W. R. Mackenzie

      Pages 1-8

3. Description — Epidemiology — Ecology — Diagnosis

   1. Front Matter

      Pages 9-9

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   2. Aspergillus: Diagnosis and Description of the Genus

      • K. J. Kwon-Chung

      Pages 11-21

   3. Epidemiology of Aspergillosis

      • H. P. R. Seeliger, K. Tintelnot

      Pages 23-34

   4. Ecology of Aspergillus Species in the Human Environment

      • Nicole Nolard, Monique Detandt, Hugues Beguin

      Pages 35-41

   5. Serodiagnosis of Aspergillosis

      • Veronica M. Hearn

      Pages 43-71

4. Immunology — Pathology — Host Defence

   1. Front Matter

      Pages 73-73

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   2. The Immunologic Significance of Aspergillus fumigatus Fractions

      • Sotiros D. Chaparas, Sang Jae Kim

      Pages 75-85

   3. Allergic Aspergillosis

      • W. J. Stevens

      Pages 87-95

   4. Pulmonary Aspergillosis — The Clinical Spectrum

      • R. J. Hay

      Pages 97-105

   5. Aspergilloma

      • Armand De Coster, Paul Dierckx, André Grivegnée

      Pages 107-114

   6. Role of the Phagocyte in Host Defense against Aspergillosis

      • John E. Bennett

      Pages 115-119

   7. Host Tissue Responses to Pathogenic and Non-Pathogenic Fungi, Including Aspergilli

      • H. Takahashi, K. Chikakane, S. Hanawa, M. Okuda, M. Hatano, K. Kikuchi et al.

      Pages 121-128

   8. Aspergillus Proteases and Aspergillosis

      • Eric D. Spitzer, George S. Kobayashi

      Pages 129-132

5. Biochemistry — Mechanisms Of Action — Morphology

   1. Front Matter

      Pages 133-133

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   2. Sterol Metabolism in Aspergillus Species

      • Michael A. Gealt, Brian E. Shapiro, Theresa A. Lindley, Joseph L. Evans

      Pages 135-145

   3. Polyene Macrolide Antibiotics

      • David Kerridge

      Pages 147-160

   4. The Mechanism of Action of Amphotericin

      • G. Medoff

      Pages 161-164

   5. Mode of Action of 5-Fluorocytosine in Aspergillus Fumigatus

      • Annemarie Polak

      Pages 165-170

Species of aspergilli are common in man's environment and are responsible for a wide spectrum of human and animal disease, ranging in animals from mycotic abortion to aflatoxicosis and in humans from localized colonization of the ear or skin to life-threatening systemic infection of neutropenic patients. In recent times, invasive aspergillosis has become increasingly important as a cause of morbidity and death, initially in patients receiving immunosuppression prior to organ transplantation, and latterly in haematologic patients rendered neutropenic by underlying disease or chemotherapy. In some centres, the condition has been recorded in more than 40% of patients dying with acute leukaemia. Laboratory diagnostic procedures are not always helpful and the diagnosis depends largely on clinical parameters. The clinician is faced with yet another problem, that of management. At present, antifungal therapy of invasive aspergillosis can be largely ineffectual, and the mortality rate remains unacceptably high. Since Aspergillus fumigatus was first described almost 125 years ago, several other pathogenic species have been recognized. The marked biosynthetic abilities and varied mechanisms of gene recombination of aspergilli have long commanded attention in food technology and genetics. Their equally varied abilities to cause disease have attracted the interest of toxicologists, allergists and physicians concerned with infectious diseases.

• animals
• environment
• food
• gene
• genes
• genetics
• immunosuppression
• infection
• infectious disease

• Janssen Research Foundation, Beerse, Belgium

  Hugo Bossche, Geert Cauwenbergh

• Mycological Reference Laboratory, London, UK

  Donald W. R. Mackenzie

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